Substituted aminophenylsulfonamide compounds as HIV protease inhibitor

US8084494B2 · kind B2 · utility

Assignee

• Tibotec Pharmaceuticals Ltd. · IE

Inventors

• Herman Augustinus De Kock · Arendonk, BE
• Tim Hugo Maria Jonckers · Heist-op-den-Berg, BE
• Stefaan Julien Last · Lint, BE
• Paul Jozef Gabriel Maria Boonants · Mechelen, BE
• Dominique Louis Nestor Ghislain Surleraux · Braine-le-Comte, BE
• Piet Tom Bert Paul Wigerinck · Terhagen, BE

Key dates

• Filing date: Nov 28, 2006
• Grant date: Dec 27, 2011
• Expiry date: Nov 13, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention concerns substituted aminophenylsulfonamide compounds, their use as protease inhibitors, in particular as broad-spectrum HIV protease inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnostic kits comprising them. The present invention also concerns combinations of the present substituted aminophenylsulfonamide compounds with another anti-retroviral agent. It further relates to their use in assays as reference compounds or as reagents.