Regulated apoptosis

US8084596B2 · kind B2 · utility

Assignees

• The Board of Trustees of the Leland Stanford Junior University · US
• President and Fellows of Harvard College · US

Inventors

• Gerald R. Crabtree · Woodside, US
• Peter Belshaw · Madison, US
• Stuart L. Schreiber · Cambridge, US
• David Spencer · Houston, US
• Thomas J. Wandless · Cambridge, US

Key dates

• Filing date: Jan 7, 2010
• Grant date: Dec 27, 2011
• Expiry date: Jan 7, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/90
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins and disclose methods and materials for using that procedure to regulatably initiate cell-specific apoptosis (programmed cell death) in genetically engineered cells.