3-Pyrrolo[b]cyclohexylene-2-dihydroindolinone derivatives and uses thereof

US8084621B2 · kind B2 · utility

Assignee

• JIANGSU SIMCERE PHARMACEUTICAL CO., LTD. · CN

Inventors

• Feng TANG · 安丰镇, CN
• Han Shen · Lansdale, US
• Qiu JIN · Cupertino, US
• Lei Ding · Plano, US
• Jie Yang · Foster City, US
• Xiaojin Yin · Nanjing, CN
• Shiyue Lu · 安丰镇, CN

Key dates

• Filing date: Dec 3, 2007
• Grant date: Dec 27, 2011
• Expiry date: Dec 3, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

3-pyrrolo[b]cyclohexylene-2-dihydro-indolinone derivatives of formula (I) or their pharmaceutically acceptable salts and uses thereof. The intermediates of formula (II) for preparing the above compounds. The bioassay shows that the above compounds and their pharmaceutically acceptable salts can modulate the activity of protein kinases (PKs), inhibit the activity of tyrosine kinases (PTKs) and inhibit many kinds of tumor cells as well as.