Progenitor endothelial cell capturing with a drug eluting implantable medical device
US8088060B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 15, 2006 |
| Grant date | Jan 3, 2012 |
| Priority date | — |
| Expiry date | Dec 14, 2026 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2300/256
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is provided with a coating with a pharmaceutical composition containing a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises one or more barrier layers, and a ligand such as a peptide, an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.