Human immortalised neural precursor cell line
US8088567B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Mar 30, 2006 |
| Grant date | Jan 3, 2012 |
| Priority date | — |
| Expiry date | Oct 11, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2533/52
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to an immortalized human neural precursor cell line, NGC-407. The cell line has been established from human foetal tissue. The cell line has been immortalized using a retroviral vector containing the v-myc oncogene. The cell line is a neural progenitor cell line capable of differentiating into to astrocytes and neurons including dopaminergic neurons. NGC-407 cells are capable of migrating to glioblastoma tumours implanted into rat brains and form gap junctions with the tumour cells. NGC-407 cells expressing a suicide gene can be be used for delivering activated prodrugs in the form of activated nucleoside analogs to tumours.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.