Patent · US Active

Ketoreductases for the production of (S,E)-methyl 2-(3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-hroxypropyl)benzoate

US8088610B2 · kind B2 · utility

29Cited by

20References

14Claims

0Family size

Assignee

Codexis, Inc. · US

Inventors

Jack Liang · San Mateo, US
Birthe Borup · Wesel, DE
Vesna Mitchell · San Jose, US
Emily Mundorff · Garden City, US
James Lalonde · Palo Alto, US
Gjalt W. Huisman · Redwood City, US

Key dates

Filing date	Sep 29, 2008
Grant date	Jan 3, 2012
Priority date	—
Expiry date	Jan 19, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12P17/12
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.