Method for reducing the risk, lessening the symptom, or delaying the onset of insulin resistance by administering SS-31
US8088727B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Feb 6, 2009 |
| Grant date | Jan 3, 2012 |
| Priority date | — |
| Expiry date | Feb 6, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/1019
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides methods of preventing or treating insulin resistance in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3pm is the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 2a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.