Analogue compounds of archaebacterial membrane lipids and liposomal compounds integrating such compounds

US8088747B2 · kind B2 · utility

Assignees

• ECOLE NATIONALE SUPÉRIEURE DE CHIMIE DE RENNES · FR
• Universite De Bretagne Occidentale · FR

Inventors

• Thierry Benvegnu · Rennes, FR
• Daniel Plusquellec · Chantepie, FR
• Gildas Rethore · Nantes, FR
• Mickaelle Scahet · Le Mans, FR
• Claude Ferec · Plougastel-Daoulas, FR
• Tristan Montier · Brest, FR
• Pascal Delepine · Heather Lane, FR
• Pierre Lehn · Paris, FR

Key dates

• Filing date: Dec 7, 2005
• Grant date: Jan 3, 2012
• Expiry date: Oct 1, 2027

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a compound of general formula (I): where X=0 or 1, Z=O, S or CH2, R1 and R2 independently=OH or OY, where Y=a protecting group, OR3, where R3=a monosaccharide or disaccharide group, A1-CH2—N+(CH3)3, X′, where X=halogen, A1=an amide (NHC(O)) or ester (OC(C)) bond, OPO(OM)2, where M=an alkyli or alkyli earth metal, OP(O)O−—O(CH2)2—N+(CH3)3, A2-(PEGX1-A3)n-R4, where n=0 or 1, PEGX1=a polyethyleneglycol of molecular weight X1, where X1 being less than or equal to 5,000 daltons, A2 and A3 independently=a ether (O), ester (OC(O)), amide (NHC(O)), urea (NHC(O)NH), thiourea (NHC(S)NH), or thioether (S) bond R4=a directing agent.