Sulfonamides and their use as a medicament

US8088772B2 · kind B2 · utility

Assignee

• The Genetics Company, Inc. · CH

Inventors

• Gabriel Garcia · Fullerton, US
• Pierre Daram · Uetikon am See, CH
• Barbara Froesch · Mettmenstetten, CH
• Frank JASCHINSKI · Puchheim, DE
• Guy Lemaillet · Meilen, CH
• Cornelia Marty-Ernst · Binz, CH
• Elena Marzi · Birkenfeld, DE
• Leonardo Scapozza · Worb, CH

Key dates

• Filing date: Dec 11, 2007
• Grant date: Jan 3, 2012
• Expiry date: Dec 11, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D333/58
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to the use of a sulfonamide compound of formula (I): wherein R1 is selected from the group consisting of H, CN, halogen, trifluoromethyl, methyl, ethyl, hydroxy, methoxy, ethoxy, morpholino, R2 is selected from H, phenyl, substituted phenyl, CN, —SO2R, wherein R is phenyl or morpholino, —NC(O)Me, —NC(O)Et, —CH2C(O)OMe, CH2C(O)OEt, R3 is selected from the group consisting of H, NO2, NH2, halogen, —COOMe, —COOEt, RC(O)N—, morpholino, R4 is selected from the group consisting of H, a branched or unbranched methyl, ethyl, propyl, butyl, pentyl, methoxy, ethoxy, propoxy, butoxy, a substituted or unsubstituted phenyl, alkinyl, Me2SO2—, COOR, wherein R is a branched or unbranched methyl, ethyl, propyl, butyl, pentyl, -MeOC(O)—, a substituted or unsubstituted five or sixmembered aromatic or non-aromatic heterocyclic system with one, two or three heteroatoms, a hetaryl system, a condensed benzoheterocyclic system, X is a linker comprising 2 or 3 atoms, selected from the group consisting of —NH—NH—, —NH—NH—CH2—, ethinyl, —NH—C(O)—CH2—, —NH—NH—SO2—, —C(O)—NH—CH2—, —NH—N═CH—, —NH—N═C(Me)-, a —NH—N═CH— motif being part of a heterocyclic system, preferably a substitu…