Substituted fused[1,2] imidazo[4,5-c] ring compounds and methods

US8088788B2 · kind B2 · utility

Assignee

• 3M INNOVATIVE PROPERTIES COMPANY · US

Inventors

• Tushar A. Kshirsagar · Woodbury, US
• Karl J. Manske · Saint Paul, US
• Larry R. Krepski · White Bear Lake, US
• Joan T. Moseman · Lake Elmo, US
• George W. Griesgraber · Eagan, US
• Sarah J. Slania · Eagan, US
• Scott E. Langer · Saint Paul, US
• Philip D. Heppner · Woodbury, US

Key dates

• Filing date: Mar 14, 2007
• Grant date: Jan 3, 2012
• Expiry date: Dec 26, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/22
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

[1,2]Imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and imidazo[4,5-c]pyridines) substituted with a fused ring containing an oxygen and/or nitrogen atom attached at the 1- and/or 2-position, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.