Substituted amide derivatives and methods of use

US8088794B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• Tae-Seong Kim · Yongin-si, KR
• David Bauer · Sudbury, US
• Steven Bellon · Wellesley, US
• Alessandro Boezio · Somerville, US
• Shon Booker · Thousand Oaks, US
• Deborah Choquette · Medford, US
• Derin D'Amico · Newbury Park, US
• Noel D'Angelo · Thousand Oaks, US
• Celia Dominguez · Los Angeles, US
• Ingrid M. Fellows · Fresno, US
• Julie Germain · Medford, US
• Russell Graceffa · Hampton, US
• Jean-Christophe Harmange · Poissy, FR
• Satoko Hirai · Brookline, US
• Daniel La · Brookline, US
• Matthew Lee · Calabasas, US
• Longbin Liu · Thousand Oaks, US
• Mark H. Norman · Thousand Oaks, US
• Michele Potashman · Cambridge, US
• Philip M. Roveto · San Francisco, US
• Aaron C. Siegmund · Ventura, US
• Ning Xi · Newbury Park, US
• Kevin Yang · San Gabriel, US

Key dates

• Filing date: Nov 12, 2010
• Grant date: Jan 3, 2012
• Expiry date: Nov 12, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.