Substituted N-phenyl-bipyrrolidine carboxamides and therapeutic use thereof

US8088808B2 · kind B2 · utility

Assignee

• Sanofi · FR

Inventors

• Werngard Czechtizky · Frankfurt, DE
• Zhongli Gao · Flemington, US
• William Joseph Hurst · Oxford, US
• Lothar Schwink · Stadtallendorf, DE
• Siegfried Stengelin · Frankfurt am Main, DE

Key dates

• Filing date: Mar 15, 2010
• Grant date: Jan 3, 2012
• Expiry date: Mar 15, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention discloses and claims a series of substituted N-phenyl-bipyrrolidine carboxamides of formula (I).Wherein R, R1, R2, R3 and R4 are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, this invention also discloses methods of preparation of substituted N-phenyl-bipyrrolidine carboxamides and intermediates therefor.