Forms of CDDO methyl ester
US8088824B2 · kind B2 · utility
50Cited by
2References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 13, 2008 |
| Grant date | Jan 3, 2012 |
| Priority date | — |
| Expiry date | Oct 19, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J63/008
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A triterpenoid compound, methyl 2-cyano-3,12-dioxoleana-1,9(11)-dien-28-oate (CDDO methyl ester), has a non-crystalline, glassy solid form and a non-hydrous crystalline form that can prepared, for example, from a saturated methanol solution. The glassy form displays an enhanced bioavailability over the non-hydrous crystalline form. Each form of CDDO methyl ester is a superior candidate for use, typically in solid dosage form, for treating a variety of disease states, generally associated with inflammation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.