Peptide-conjugates that bind to VEGF-stimulated or tumor vasculature and methods of treatment
US8088887B2 · kind B2 · utility
1Cited by
12References
22Claims
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Key dates
| Filing date | Apr 13, 2007 |
| Grant date | Jan 3, 2012 |
| Priority date | — |
| Expiry date | Apr 5, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/57423
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides nucleic acids, peptides, and antibodies for use in applications including diagnosis and therapy. The peptides target neovasculature and were identified by in vivo phage display. One such peptide, SP5-52, recognized the neovasculature of multiple tumors in SCID mice, but did not target normal blood vessels. This peptide also binds to blood vessels of human lung cancer biopsy specimens. Liposomes comprising SP5-52 and doxorubicin enhanced the efficacy of the drug against multiple human cancer xenografts in SCID mice.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.