Detection of mutations in a gene associated with resistance to viral infection, OAS1
US8088907B2 · kind B2 · utility
3Cited by
4References
1Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 2, 2008 |
| Grant date | Jan 3, 2012 |
| Priority date | — |
| Expiry date | Nov 3, 2028 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for detecting a mutation related to the gene encoding OAS1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the mutated gene, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human OAS1, including antisense oligonucleotides, methods, and compositions specific for human OAS1, are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.