Small molecule inhibitors of MDM2 and the uses thereof

US8088931B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Shaomeng Wang · Saline, US
• Ke Ding · 流花街道, CN
• Yipin Lu · Emeryville, US
• Zaneta Nikolovska-Coleska · Ann Arbor, US
• Su Qiu · Ann Arbor, US
• Guoping Wang · Naperville, US
• Dongguang Qin · Auburn Hills, US
• Sanjeev Kumar · Ann Arbor, US

Key dates

• Filing date: Jun 24, 2010
• Grant date: Jan 3, 2012
• Expiry date: Jun 24, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).