Matrix for separation of polyethers and method of separation
US8092682B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 21, 2009 |
| Grant date | Jan 10, 2012 |
| Priority date | — |
| Expiry date | Aug 10, 2030 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01D15/424
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
The present invention relates to a separation matrix comprised of a support to the surfaces of which polymer chains have been coupled, wherein each polymer chain presents recurring proton-donating groups and at least the surface of the support is substantially hydrophilic. In the most advantageous embodiment, the support is porous cross-linked agarose, the polymers are poly(acrylic acid) and the proton-donating groups are carboxyl groups. The matrix is useful e.g. to remove PEG from pegylated and/or native compounds in a liquid. Accordingly, the invention also encompasses a method, such as a chromatographic method, wherein the separation matrix according to the invention is used, for example as a pre-treatment of a reaction mixture that comprises unreacted PEG, pegylated proteins and native proteins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.