Systems and methods of microfluidic membraneless exchange using filtration of extraction outlet streams

US8092684B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Edward F. Leonard · Scarsdale, US
• Alan C. West · Tenafly, US
• Christian P. Aucoin · New York, US
• Edgar E. Nanne · The Bronx, US

Key dates

• Filing date: Nov 17, 2010
• Grant date: Jan 10, 2012
• Expiry date: Nov 17, 2030

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2030/0045
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.