Solid pharmaceutical composition comprising (R)-(−)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman

US8093270B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Klaus Kunath · Zwingenberg, DE
• Kirstin Heil · Darmstadt, DE
• Roland Rupp · Bensberg, DE

Key dates

• Filing date: Jun 9, 2006
• Grant date: Jan 10, 2012
• Expiry date: Aug 24, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a solid pharmaceutical preparation containing (R)-(−)-2-[5-(4-fluorophenyl-3-pyridylmethylaminomethyl]chroman as an active substance and at least one sugar alcohol (e.g. mannitol, sorbitol) as a filler. Also disclosed is the production of said solid pharmaceutical preparation, which is provided with an increased shelf life also at elevated temperatures and can be used for the treatment of dyskinesia associated with Parkinson's disease.