Dbait and standalone uses thereof

US8093366B2 · kind B2 · utility

Assignees

• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · FR
• INSTITUT CURIE · FR
• MUSEUM NATIONAL D'HISTOIRE NATURELLE · FR
• Institut National de la Sante et de la Recherche Medicale (INSERM) · FR

Inventors

• Marie Dutreix · L'Haÿ-les-Roses, FR
• Jian Sun · Saint-Maur-des-Fossés, FR

Key dates

• Filing date: Jan 11, 2008
• Grant date: Jan 10, 2012
• Expiry date: Jan 11, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/53
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to compositions and methods for interfering with the DNA repair of double strand breaks (DSBs). The invention discloses double-stranded nucleic acid molecules that act as baits and hijack the holocomplex of enzymes responsible for DNA DSB sensing, signaling and/or repair pathways, in particular the non-homologous end joining (NHEJ) pathway of DSB repair. The invention discloses the use of these molecules as a standalone anticancer drug in an efficient amount to be introduced in the tumor cell nuclei in order to trigger their death.