Dipeptidyl peptidase inhibitors

US8093382B2 · kind B2 · utility

Assignee

• Takeda Pharmaceutical Company Limited · JP

Inventors

• Jun Feng · San Diego, US
• Stephen L. Gwaltney · San Diego, US
• Michael B. Wallace · San Diego, US
• Jeffrey Alan Stafford · San Diego, US
• Zhiyuan Zhang · Beijing, CN

Key dates

• Filing date: Dec 9, 2010
• Grant date: Jan 10, 2012
• Expiry date: Dec 9, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a member selected from the group consisting of:wherein E is CH or N, Q is selected from the group consisting of CO, CS, SO, SO2, or C═NR4, and L, X, Z, R2 and R3 are as defined herein.