Specific binding molecules for scintigraphy, conjugates containing them and therapeutic method for treatment of angiogenesis
US8097254B2 · kind B2 · utility
10Cited by
49References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 12, 2004 |
| Grant date | Jan 17, 2012 |
| Priority date | — |
| Expiry date | Dec 30, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/622
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to antibodies with sub-nanomolar affinity specific for a characteristic epitope of the ED-B domain of fibronectin, a marker of angiogenesis. Furthermore, it relates to the use of radiolabelled high affinity anti ED-B antibodies for detecting new-forming blood vessels in vivo and a diagnostic kit comprising said antibody. Furthermore, it relates to conjugates comprising said antibodies and a suitable photoactive molecules (e.g. an appropriately chosen photosensitizer or radionuclide), and their use for the selective light-mediated occlusion of new blood vessels.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.