α-MSH-antagonist dipeptide conjugates

US8097590B2 · kind B2 · utility

Assignees

• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · FR
• Institut European de Biologic Cellulaire · FR
• Universite De Montpellier · FR

Inventors

• Anne-Marie Pinel · Toulouse, FR
• Pascal Verdie · Castelnau-le-Lez, FR
• Pascaline Dubs · Montpellier, FR
• Jean Martinez · Caux, FR
• Gilles Subra · Juvignac, FR

Key dates

• Filing date: May 10, 2005
• Grant date: Jan 17, 2012
• Expiry date: Jun 26, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2800/57
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a dipeptide conjugate having general formula I, AA2-AA1-NH2, wherein A represent the radical corresponding to a monocarboxylic acid with general formula II, HOOC—R, in which: R represents a linear or branched aliphatic radical at C1-C24, which is optionally substituted by a hydroxyl group and which can comprise one or more unsaturations, preferably between 1 and 6 unsaturations, and/or which can comprise a phenyl group or lipoic acid or the reduced form thereof, dihydrolipoic acid or N-lipoyllysine; and AA1 and AA2 represent identical or different amino acids which are selected from the group containing Ala, Asn, Cys, Gln, Gly, Ile, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, Val, Asp, Glu, Arg, His, Lys, Orn, Dap, Dab, the corresponding homo-amino acids and the corresponding beta-amino acids in the form of enantiomers or diastereoisomers and mixtures thereof, including racemic mixtures.