Patent · US Active

Compositions and methods for detecting phosphomonoester

US8101375B2 · kind B2 · utility

0Cited by
6References
20Claims
0Family size

Assignee

Inventors

Key dates

Filing dateAug 25, 2010
Grant dateJan 24, 2012
Priority date—
Expiry dateAug 25, 2030

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07K1/13
  • WIPO fieldMeasurement
  • WIPO sectorInstruments

Abstract

The invention provides a method of modifying a phosphomonoester moiety of a target compound. The method can include the steps of (a) providing a target compound having an electrophilic moiety and a phosphomonoester moiety; (b) contacting the target compound with a first carbodiimide compound under conditions for preferential addition of the first carbodiimide compound to the electrophilic moiety over the phosphomonoester moiety, thereby forming an electrophile-protected target compound; and (c) contacting the electrophile-protected target compound with a second carbodiimide compound and a nucleophilic compound under conditions for addition of the nucleophilic compound to the phosphomonoester.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.