Compositions for detection and analysis of polynucleotides using light harvesting multichromophores
US8101416B2 · kind B2 · utility
60Cited by
6References
23Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 8, 2007 |
| Grant date | Jan 24, 2012 |
| Priority date | — |
| Expiry date | Nov 30, 2029 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/143333
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor PNA complementary to the target polynucleotide. A signaling chromophore absorbs energy from the excited multichromophore and emits light in the presence of the target polynucleotide. The methods can be used in multiplex form. Kits having reagents for performing such methods are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.