Compounds and compositions as protein kinase inhibitors

US8101608B2 · kind B2 · utility

Assignee

• IRM LLC, a Delaware Limited Liability Company · BM

Inventors

• Yongqin Wan · Irvine, US
• Yuan Mi · San Diego, US
• Yi Fan · Lawrence, US
• Dai Cheng · San Diego, US
• Yi Liu · San Diego, US
• Nathanael S. Gray · Boston, US
• Pamela Albaugh · Carmel, US

Key dates

• Filing date: Nov 7, 2005
• Grant date: Jan 24, 2012
• Expiry date: Jan 9, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-II, Rsk1, SGK, TrkA, TrkB and TrkC kinases.