1,4-diaryl-dihydropyrimidin-2-ones and their use as human neutrophil elastase inhibitors

US8101615B2 · kind B2 · utility

Assignee

• Bayer Pharma Aktiengesellschaft · DE

Inventors

• Heike Gielen-Haertwig · Monheim, DE
• Barbara Albrecht · Wuppertal, DE
• Jörg Keldenich · Wuppertal, DE
• Volkhart Min-Jian Li · Velbert, DE
• Josef Pernerstorfer · Wuppertal, DE
• Karl-Heinz Schlemmer · Wuppertal, DE
• Leila Telan · Wuppertal, DE

Key dates

• Filing date: Feb 15, 2005
• Grant date: Jan 24, 2012
• Expiry date: Feb 4, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to novel heterocyclic derivatives of the general formula (I), processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.