Antibodies blocking fibroblast growth factor receptor activation and methods of use thereof
US8101721B2 · kind B2 · utility
11Cited by
18References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 17, 2007 |
| Grant date | Jan 24, 2012 |
| Priority date | — |
| Expiry date | Aug 20, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/76
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention is related to antibodies with binding affinity to fibroblast growth factor receptor 2 (FGFR2) optionally with binding affinity to other FGF receptors, which block both ligand-dependent and constitutive ligand independent receptor activation. Specifically, the present invention relates to antibodies with high affinity to more than one FGF receptor subtype, and fragments thereof, useful in treating disorders including cell proliferative diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.