Protease resistant modified IFN beta polypeptides and their use in treating diseases
US8105573B2 · kind B2 · utility
1Cited by
51References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 26, 2011 |
| Grant date | Jan 31, 2012 |
| Priority date | — |
| Expiry date | Jan 26, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Protease resistant modified interferon-beta polypeptides, and pharmaceutical compositions containing such modified interferon-beta polypeptides are provided. The modified interferon-beta polypeptides contain amino acid substitutions that confer increased resistance to proteolysis over unmodified IFN beta cytokine molecules. The present invention provides for pharmaceutical formulations suitable for oral, nasal and pulmonary administration, and the use of such formulations in the treatment of disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.