IL-1 gene cluster and associated inflammatory polymorphisms and haplotypes
US8105775B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 25, 2006 |
| Grant date | Jan 31, 2012 |
| Priority date | — |
| Expiry date | Jun 25, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/172
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides methods and compositions relating to identification and use of genetic information from the IL-I gene cluster—including the structure and organization of novel IL-I-like genes found within the IL-I locus as well as polymorphisms and associated haplotypes within these genes. The invention thereby expands the repertoire of useful genetic information available from the IL-I locus—which contains the previously-identified IL-1α, EL-1β and IL-IRN genes, for predicting IL-I associated phenotypes (e.g. increased or decreased risks of inflammatory disease) and for treating IL-I haplotype associated inflammatory phenotypes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.