Metal complex phosphatidyl-inositol-3-kinase inhibitors

US8106039B2 · kind B2 · utility

Assignees

• The Trustees of the University of Pennsylvania · US
• The Wistar Institute of Anatomy and Biology · US

Inventors

• Eric Meggers · Philadelphia, US
• Peng Xie · Xiamen, CN
• Douglas S. Williams · Durham, US
• Ronen Marmorstein · Swarthmore, US

Key dates

• Filing date: Apr 30, 2008
• Grant date: Jan 31, 2012
• Expiry date: Nov 27, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Provided are novel organometallic compounds that inhibit PI3K lipid kinase and phospho-AKT in human melanoma cells, and also inhibit the migration of melanoma cells. The present invention is also directed to methods for inhibiting cancer cell proliferation, migration or both comprising contacting a cancer cell with a disclosed organometallic kinase inhibitor. Also disclosed are methods for treating a kinase-affected disease or condition comprising administering to a subject in need thereof a therapeutically effective amount of a disclosed organometallic kinase inhibitor.