Substituted pyrazines that inhibit protease cathepsin S and HCV replication
US8106059B2 · kind B2 · utility
4Cited by
0References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 22, 2008 |
| Grant date | Jan 31, 2012 |
| Priority date | — |
| Expiry date | Mar 30, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D403/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention is directed to compounds of formula I, below, that have the dual property of acting as cathepsin S inhibitors and of inhibiting HCV replication. Such compounds are therefore useful in treating disease states that include hepatitis C, Alzheimer's disease, and autoimmune disorders. The present invention is also directed to pharmaceutical compositions containing these compounds, and processes for preparing the compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.