Compositions and methods for enhancing nitric oxide delivery
US8106080B2 · kind B2 · utility
3Cited by
0References
13Claims
0Family size
Inventors
Key dates
| Filing date | Jun 8, 2006 |
| Grant date | Jan 31, 2012 |
| Priority date | — |
| Expiry date | May 31, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P21/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to compounds, combinations, compositions and methods for enhancing nitric oxide (NO) delivery to target sites, and in particular to muscle, both normal and dystrophic. Enhanced NO delivery according to the present invention may be achieved by using a combination of a muscle relaxant and an NO donor compound, or by using a compound of the invention: formula (I) wherein R1 is H, halo, C1-6 alkoxy or C1-6 alkyl; R2 is H, NO2 or C(O)NH2; R3 is H, NO2 or C(O)NH2; and at least one of R2 and R3 is NO2; or a pharmaceutically acceptable salt of the compound.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.