Synthesis and anti-proliferative effect of benzimidazole derivatives
US8106084B2 · kind B2 · utility
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6References
12Claims
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Inventor
Key dates
| Filing date | Mar 3, 2011 |
| Grant date | Jan 31, 2012 |
| Priority date | — |
| Expiry date | Mar 3, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention provides for compounds, compositions, and methods that involve anti-proliferative and anti-neoplastic activity in cancer cells. In particular, a series of benzimidazole, purine, imidazopyridine, and imidazopyrazine compounds having selected substitution patterns are disclosed, and the activity of various subject compounds is demonstrated. For example, the invention provides compounds having the general formula:their pharmaceutical compositions, and methods of treatment using the subject compounds and compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.