N[S(4-aryl-triazol-3-yl)α-mercaptoacetyl]p-amino benzoic acids as HIV reverse transcriptase inhibitors

US8106205B2 · kind B2 · utility

Assignee

• Ardea Biosciences, Inc · US

Inventors

• Jean-Luc Girardet · San Diego, US
• Yung-hyo Koh · Irvine, US
• Martha Alicia De La Rosa · Morrisville, US
• Zhi Hong · Chapel Hill, US
• Stanley Lang · Carlsbad, US

Key dates

• Filing date: Feb 2, 2010
• Grant date: Jan 31, 2012
• Expiry date: Feb 2, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D249/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A series of S-triazolyl α-mercaptoacetanilides having N-(α-mercaptoacetyl) p amino benzoic acid derivatives.are provided, where Q is CO2H, or a salt or ester thereof, or a C(O) N-linked amino acid. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.