Patent · US Active

Collections of repeat proteins comprising repeat modules

US8110653B2 · kind B2 · utility

22Cited by

0References

9Claims

0Family size

Assignee

Universitat Zurich · CH

Inventors

Michael Tobias Stumpp · Geroldswil, CH
Patrik Forrer · Schlieren, CH
Hans Kasper Binz · Birmensdorf, CH
Andreas Plückthun · Zürich, CH

Key dates

Filing date	Aug 11, 2008
Grant date	Feb 7, 2012
Priority date	—
Expiry date	Aug 11, 2028

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N15/1093
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A collection of repeat proteins, each repeat protein comprising a repeat domain, which comprises a set of consecutive repeat modules, wherein each of the repeat modules is derived from one or more repeat units and wherein the repeat units comprise framework residues, which contribute to the folding topology of the repeat unit or contribute to an interaction with a neighboring repeat unit, and target interaction residues, which contribute to an interaction with a target substance, wherein the repeat proteins differ from other repeat proteins in the collection in at least one amino acid position of the repeat modules is described.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.