Industrial process for the synthesis of 17α-acetoxy-11β-[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna-4,9-diene-3,20-dione and new intermediates of the process
US8110691B2 · kind B2 · utility
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Key dates
| Filing date | May 18, 2007 |
| Grant date | Feb 7, 2012 |
| Priority date | — |
| Expiry date | Oct 31, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J71/001
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A new industrial process for the synthesis of solvate-free 17α-acetoxy-11β-[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna-4,9-diene-3,20-dione [CDB-2914] of formula (I)which is a strong antiprogestogene and antiglucocorticoid agent. The invention also relates to compounds of formula (VII)and (VIII)used as intermediates in the process.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.