Medical devices for delivery of therapeutic agent in conjunction with galvanic corrosion
US8114148B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 23, 2009 |
| Grant date | Feb 14, 2012 |
| Priority date | — |
| Expiry date | Mar 2, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2300/00
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
According to an aspect of the present invention, at least one ionic therapeutic agent is delivered from an implantable or insertable medical device that comprises an ion-conductive polymeric region that is disposed on a metallic region. The metallic region is in electrical contact with a dissimilar metallic region, such that a galvanic current is generated by the dissimilar metals when the device is implanted or inserted into a patient. Delivery of the ionic therapeutic agent from the ion-conductive polymeric region may be, for example, either accelerated or retarded by the galvanic current. According to another aspect of the present invention, implantable or insertable medical devices are provided which comprise: (a) a first metallic region having a first corrosion potential, (b) a second metallic region in electrical contact with the first metallic region and having a second corrosion potential that is greater than the first corrosion potential, and (c) a solid ion-conductive polymeric region, comprising an ion conducting polymer and an ionic therapeutic agent, disposed on the first metallic region, the second metallic region, or both.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.