Label-free high throughput biomolecular screening system and method

US8114348B2 · kind B2 · utility

Assignee

• CORNING INCORPORATED · US

Inventors

• Stephen J. Caracci · Elmira, US
• Volker H.O. Eckelt · Jena, DE
• Anthony G. Frutos · Corning, US
• Mark Francis Krol · Corning, US
• Thomas C. Moore · Livermore, US
• David Andrew Pastel · Horseheads, US
• Gordon M. Shedd · Lawrenceville, US

Key dates

• Filing date: Jun 9, 2009
• Grant date: Feb 14, 2012
• Expiry date: Oct 14, 2029

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2035/0097
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occur in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices to help perform automated HTS assays.