Heterologous expression of Neisserial proteins

US8114960B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Maria Arico · Quercegrossa, IT
• Maurizio Comanducci · Siena, IT
• Cesira Galeotti · Poggibonsi, IT
• Vega Masignani · Siena, IT
• Marzia Monica Guiliani · Siena, IT
• Mariagrazia Pizza · Siena, IT

Key dates

• Filing date: Jun 28, 2010
• Grant date: Feb 14, 2012
• Expiry date: Jun 28, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/156
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Alternative and improved approaches to the heterologous expression of the proteins of Neisseria meningitidis and Neisseria gonorrhoeae. These approaches typically affect the level of expression, the ease of purification, the cellular localization, and/or the immunological properties of the expressed protein.