Process for preparing difluoromethylpyrazolyl carboxylates

US8115012B2 · kind B2 · utility

Assignee

• BASF SE

Inventors

• Martin Sukopp · Mannheim, DE
• Michael Rack · Eppelheim, DE
• Sebastian Peer Smidt · Mannheim, DE
• Sandra Löhr · Ludwigshafen, DE
• Michael Keil · Freinsheim, DE
• Jochen Dietz · Karlsruhe, DE
• Joachim Rheinheimer · Ludwigshafen, DE
• Thomas Grote · Monsheim, DE
• Thomas Zierke · Böhl-Iggelheim, DE
• Jan Klaas Lohmann · Lambsheim, DE

Key dates

• Filing date: Nov 2, 2007
• Grant date: Feb 14, 2012
• Expiry date: May 23, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D231/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for preparing difluoromethyl-substituted pyrazol-4-ylcarboxylates of the formula Iin which in which X is fluorine, chlorine or bromine, R1 has one of the meanings given above and R4 is C1-C8-alkyl, C3-C8-cycloalkyl, C2-C8-alkenyl, benzyl or phenyl, is reacted with a silane compound of the general formula R3nSiCl(4-n) in which n is 1, 2 or 3 and the substituents R3 are independently of one another selected from the group consisting of C1-C8-alkyl and phenyl and with a metal selected from the metals of groups 1, 2, 3, 4 and 12 of the Periodic Table of the Elements having a redox potential of less than −0.7 V, based on a normal hydrogen electrode (at 25° C. and 101.325 kPa); and