Helper virus-free herpesvirus amplicon particles and uses thereof

US8119118B2 · kind B2 · utility

Assignee

• University of Rochester · US

Inventors

• Howard J. Federoff · Bethesda, US
• William Bowers · Webster, US
• John G. Frelinger · Pittsford, US
• Richard A. Willis · Austin, US
• Thomas G. Evans · New York, US
• Stephen Dewhurst · Rochester, US
• Khaled Tolba · Rochester, US
• Joseph Rosenblatt · Hollywood, US

Key dates

• Filing date: Oct 5, 2005
• Grant date: Feb 21, 2012
• Expiry date: Jul 2, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2710/16662
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention features new helper virus-free methods for making herpesvirus amplicon particles that can be used in immunotherapies, including those for treating any number of infectious diseases and cancers (including chronic lymphocytic leukemia, other cancers in which blood cells become malignant, lymphomas (e.g. Hodgkin's lymphoma or non-Hodgkin's type lymphomas). Described herein are methods of making helper virus-free HSV amplicon particles; cells that contain those particles (e.g., packaging cell lines or patients' cells, infected in vivo or ex vivo); particles produced according to those methods; and methods of treating a patient with an hf-HSV particle made according to those methods.