Thiadiazole-substituted arylamides as P2X3 and P2X2/3 antagonists

US8119644B2 · kind B2 · utility

Assignee

• Roche Palo Alto LLC · US

Inventors

• Li Chen · Sha Tin, CN
• Lichun Feng · Shanghai, CN
• Minmin Yang · Nanjing, CN
• Michael Patrick Dillon · Mill Valley, US
• Yingjie Lai · Edison, US

Key dates

• Filing date: Dec 12, 2009
• Grant date: Feb 21, 2012
• Expiry date: Dec 12, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula I:or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted thiadiazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.