Indenoisoquinolinone analogs and methods of use thereof

US8119654B2 · kind B2 · utility

Assignee

• Inotek Pharmaceuticals Corporation · US

Inventors

• Prakash Jagtap · North Andover, US
• Duy-Phong Pham-Huu · Beverly, US
• Frederick Cohen · San Francisco, US
• Xiaojing Wang · Foster City, US

Key dates

• Filing date: Feb 28, 2008
• Grant date: Feb 21, 2012
• Expiry date: Sep 26, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to Indenoisoquinolinone Analogs, compositions comprising an effective amount of an Indenoisoquinolinone Analog and methods for treating or preventing an inflammatory disease, a reperfusion injury, diabetes mellitus, a diabetic complication, reoxygenation injury resulting from organ transplantation, an ischemic condition, a neurodegenerative disease, renal failure, a vascular disease, a cardiovascular disease, cancer, a complication of prematurity, cardiomyopathy, retinopathy, nephropathy, neuropathy, erectile dysfunction or urinary incontinence, comprising administering to a subject in need thereof an effective amount of an Indenoisoquinolinone Analog.