Adjuvants on the basis of bisacyloxypropylcystene conjugates and derivatives and their uses in pharmaceutical compositions

US8119689B2 · kind B2 · utility

Assignee

• Helmholtz-Zentrum Für Infektionsforschung GmbH · DE

Inventors

• Thomas Ebensen · Hannover, DE
• Michael Morr · Wolfenbüttel, DE
• Carlos Guzman · Wolfenbüttel, DE

Key dates

• Filing date: Nov 22, 2006
• Grant date: Feb 21, 2012
• Expiry date: Jun 7, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Bisacyloxycysteine type conjugates have been found to be useful as adjuvants and/or immunomodulators for prophylactic and/or therapeutic vaccination in the treatment of infectious diseases, inflammatory diseases, autoimmune diseases, tumors, and allergies, as well as in the control of fertility in human or animal populations. The compounds can be administered by system or mucosal routes and are particularly useful as mucosal adjuvants. These compounds can function as active ingredients in pharmaceutical compositions.