Human anti-KIR antibodies
US8119775B2 · kind B2 · utility
38Cited by
7References
20Claims
0Family size
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Key dates
| Filing date | Oct 2, 2008 |
| Grant date | Feb 21, 2012 |
| Priority date | — |
| Expiry date | Jan 25, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/92
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9 or 1-4F1. Described also are also fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly for use in therapy, to increase NK cell activity or cytotoxicity in subjects.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.