FGF variants and methods for use thereof
US8119783B2 · kind B2 · utility
3Cited by
32References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 1, 2009 |
| Grant date | Feb 21, 2012 |
| Priority date | — |
| Expiry date | Oct 10, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2506/1346
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides fibroblast growth factor variants demonstrating enhanced receptor subtype specificity and/or affinity. Preferred embodiments include both variants having enhanced activity that act as improved agonists and variants having reduced activity that act as antagonists. Methods of utilizing preferred FGF variants in preparation of medicaments for the treatment of skeletal disorders including skeletal dysplasia, osteoporosis and enhancing bone fracture healing and cartilage healing processes are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.