Substituted disulfonamide compounds

US8119805B2 · kind B2 · utility

Assignee

• Gruenenthal GmbH · DE

Inventors

• Melanie Reich · Aachen, DE
• Stefan Schunk · Aachen, DE
• Ruth Jostock · Stolberg, DE
• Sabine Hees · Aachen, DE
• Tieno Germann · Aachen, DE
• Michael Engels · Turnhout, BE

Key dates

• Filing date: Nov 6, 2009
• Grant date: Feb 21, 2012
• Expiry date: Nov 6, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Substituted disulfonamide compounds corresponding to formula I:In which R1, R2, R3, R4a, R4b, R5a, R5b, R8, R9a, R9b, R10, R11, a, b, s, t and A have defined meanings, pharmaceutical compositions containing one or more such compounds, processes for preparing such compounds, and a method of using such compounds for the treatment or inhibition of pain and/or other conditions mediated by the bradykinin receptor 1 (BR1).