Malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
US8119819B2 · kind B2 · utility
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4Claims
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Key dates
| Filing date | Apr 28, 2009 |
| Grant date | Feb 21, 2012 |
| Priority date | — |
| Expiry date | Dec 19, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/6539
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD). In particular, the invention relates to compounds and compositions and the methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the inhibition of malonyl-coenzyme A decarboxylase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.