Single chain antibodies against β-amyloid peptide
US8124076B2 · kind B2 · utility
9Cited by
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12Claims
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Key dates
| Filing date | Aug 18, 2006 |
| Grant date | Feb 28, 2012 |
| Priority date | — |
| Expiry date | Aug 26, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/70
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Anti-AβP scFvs and single domain antibodies were generated, and when these antibodies were displayed on filamentous phage or as soluble protein molecules, stabilized by the maltose binding protein, they could prevent the fibrilization of Abp 1-40 and disaggregate Abp 1-40 fibrils generated in vitro. The anti-Aβp scFv antibodies also stained amyloid neuritic plaques on slices from transgenic mice. The anti-AβP scFv and single domain antibodies can be used for inhibiting or treating Alzheimer's disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.